Sermorelin

Sermorelin mimics the action of the body's natural GHRH.

It binds to GHRH receptors in the pituitary gland, stimulating the release of growth hormone.

This may:

• Increase natural GH secretion

• Increase downstream IGF-1 signaling

• Support the body's normal pulsatile GH release

• Influence tissue repair and metabolism

Because it stimulates the pituitary rather than supplying GH directly, the body's natural regulatory mechanisms remain involved in GH production.

MUSCLE & BODY COMPOSITION

• Lean body mass

• Fat metabolism

• Body composition

• GH and IGF-1 signaling

RECOVERY & REPAIR

• Exercise recovery

• Tissue repair

• Muscle recovery

• GH-related regenerative processes

SLEEP & WELLNESS

Some of the body's largest natural GH pulses occur during sleep.

Growth hormone pathways are involved in research examining:

• Sleep quality

• Physical recovery

• Energy and metabolism

• Healthy aging

Sermorelin stimulates the pituitary gland to produce and release the body's own growth hormone.

HGH (somatropin) supplies growth hormone directly.

This makes Sermorelin a growth hormone-releasing peptide rather than growth hormone itself.

• Injection-site redness or irritation

• Headache

• Flushing

• Dizziness

• Nausea

• Water retention

Changes in GH and IGF-1 can also affect blood sugar regulation, making appropriate monitoring important when used clinically.

Sermorelin was previously FDA-approved under the brand Geref for certain pediatric growth hormone deficiency uses. The product was later discontinued, and FDA determined that its withdrawal was not due to safety or effectiveness concerns. There is currently no FDA-approved Sermorelin product marketed in the United States.