Retatrutide

Each receptor contributes differently to appetite, metabolism, and energy balance.

GLP-1

• Helps reduce appetite and food intake

• Promotes feelings of fullness

• Supports blood sugar regulation

GIP

• Supports insulin response

• Works alongside GLP-1 to regulate metabolism

Glucagon

• Influences energy expenditure and fat metabolism

• May contribute to retatrutide's effects on body weight and metabolic health

Together, these three pathways are being studied for their combined effects on appetite, body weight, glucose control, and metabolism.

WEIGHT MANAGEMENT

• Reduced appetite and food intake

• Increased feelings of fullness

• Significant reductions in body weight demonstrated in clinical trials

METABOLIC HEALTH

• Improved insulin sensitivity

• Improved blood sugar regulation

• Potential improvements in several cardiometabolic risk factors

BODY COMPOSITION

• Reduction in overall body weight

• Reduction in body fat

• Ongoing research into its effects on metabolic health and energy balance

The most commonly reported side effects have been gastrointestinal and may include:

• Nausea

• Diarrhea

• Vomiting

• Constipation

• Decreased appetite

• Digestive discomfort

Clinical trials have also observed dose-related increases in heart rate. Gastrointestinal side effects have generally been more common during dose escalation and at higher doses.

Retatrutide remains an investigational medication. Research continues to evaluate its long-term effectiveness, safety, and potential uses.